ARE GENDER DIFFERENCES IN CARDIOVASCULAR-DISEASE RISK-FACTORS EXPLAINED BY THE LEVEL OF VISCERAL ADIPOSE-TISSUE
ARE GENDER DIFFERENCES IN CARDIOVASCULAR-DISEASE RISK-FACTORS EXPLAINED BY THE LEVEL OF VISCERAL ADIPOSE-TISSUE
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DOI：
10.1007/bf00404332
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发表时间：
1994-08-01
期刊：
影响因子：
8.2
通讯作者：
LUPIEN, PJ
中科院分区：
文献类型：
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作者：
LEMIEUX, S;DESPRES, JP;LUPIEN, PJ
有人认为，绝经前女性心血管疾病的发病率低于男性，这可能是由于身体脂肪分布、血浆脂蛋白水平和血浆葡萄糖-胰岛素稳态指数的差异。因此，在年龄23-50岁的80名男性和69名绝经前女性中，研究了通过计算机断层扫描和代谢变量测量的内脏脂肪组织积累的性别差异。尽管事实上，女性有更高水平的总身体脂肪（p < 0.0001），他们显示出较低的腹部内脏脂肪组织面积（p < 0.06）和腹部内脏脂肪组织面积与大腿中部脂肪组织面积的比率低于男性（p < 0.0001）。校正体脂后，女性的危险因素普遍高于男性，包括血浆HDL（2）-胆固醇较高，血浆胰岛素、载脂蛋白B和甘油三酯水平较低（p < 0.01）。在控制腹部内脏脂肪组织面积的差异后，比较性别间经体脂量调整的代谢变量。在这样的控制后，与血浆葡萄糖-胰岛素稳态相关的变量在男性和女性之间不再有显著差异。血浆甘油三酯、载脂蛋白B和HDL（2）-胆固醇/HDL（3）-胆固醇比值的性别差异也消失了，而血浆HDL-胆固醇、HDL（2）-胆固醇浓度以及HDL-胆固醇/总胆固醇比值女性仍显著高于男性（p < 0.01）。这些结果表明，腹部内脏脂肪组织是心血管疾病风险性别差异的重要相关因素。然而，其他因素可能涉及血浆HDL-胆固醇水平的性别差异。
It has been suggested that the lower prevalence of cardiovascular disease in women before menopause in comparison with men may be explained by differences in body fat distribution, plasma lipoprotein levels and indices of plasma glucose-insulin homeostasis. Thus, gender differences in visceral adipose tissue accumulation measured by computed tomegraphy and metabolic variables were studied in 80 men and 69 pre-menopausal women, aged 23-50 years. Despite the fact that women had higher levels of total body fat (p < 0.0001), they displayed lower areas of abdominal visceral adipose tissue (p < 0.06) and a lower ratio of abdominal visceral to mid-thigh adipose tissue areas than men (p < 0.0001). After adjustment for body fat mass, women generally displayed a more favourable risk profile than men which included higher plasma HDL(2)-cholesterol and lower plasma insulin, apolipoprotein B and triglyceride levels (p < 0.01). Metabolic variables adjusted for body fat mass were then compared between genders after control for differences in abdominal visceral adipose tissue area. After such controls, variables related to plasma glucose-insulin homeostasis were no longer significantly different between men and women. Gender differences for plasma concentrations of triglyceride, apolipoprotein B and the ratio of HDL(2)-cholesterol/HDL(3)-cholesterol also disappeared, whereas plasma concentrations of HD L-cholesterol, HDL(2)-cholesterol as well as the ratio of HDL-cholesterol/total cholesterol remained significantly higher in women than in men (p < 0.01). These results suggest that abdominal visceral adipose tissue is an important correlate of gender differences in cardiovascular disease risk. However, additional factors are likely to be involved in gender differences in plasma HDL-cholesterol levels.