Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus.
Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus.
复制标题
脚桥被盖核损伤后大鼠声惊吓的前脉冲抑制。
DOI：
10.1037//0735-7044.107.1.104
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
Geyer,MA
中科院分区：
文献类型：
--
作者：
Swerdlow,NR;Geyer,MA
精神分裂症患者的惊吓前脉冲抑制（PPI）受到损害，这表明他们控制 PPI 的电路存在紊乱。研究人员探讨了前脑回路的活动如何传递至初级惊吓回路以调节 PPI。苍白球下细胞支配脚桥被盖核（PPTg）。将 γ-氨基丁酸拮抗剂印防己毒素输注到苍白球下受损的 PPI 中。在其他大鼠中，电解 PPTg 损伤会降低或消除 PPI，增强惊跳幅度，并且不会改变习惯。 PPI 的破坏与 PPTg 损伤的程度显着相关。当惊吓刺激较弱或强烈（104 或 140 db）以及前脉冲刺激范围高于背景 2 至 17 db 时，PPTg 损伤会降低 PPI，但当前脉冲高于背景 5-8 db 时，PPg 损伤最明显。 PPTg 调节感觉运动门控，并可以处理信息并将其从前脑结构传输到初级惊吓回路。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Prepulse inhibition (PPI) of startle is impaired in schizophrenics, which suggests they have disturbances in circuitry that controls PPI. How activity in forebrain circuitry is communicated to the primary startle circuit to modulate PPI was explored. Subpallidal cells innervate the pedunculopontine tegmental nucleus (PPTg). Infusion of the γ-aminobutyric acid antagonist picrotoxin into the subpallidum impaired PPI. In other rats, electrolytic PPTg lesions decreased or eliminated PPI, potentiated startle amplitude, and did not alter habituation. The disruption of PPI correlated significantly with the extent of PPTg damage. PPTg lesions reduced PPI when startle stimuli were weak or intense (104 or 140 db) and when prepulse stimuli ranged from 2 to 17 db above background but were most profound with prepulses 5–8 db above background. The PPTg modulates sensorimotor gating and may process and transmit information from forebrain structures to the primary startle curcuit.(PsycINFO Database Record (c) 2016 APA, all rights reserved)