Vascular endothelial growth factor is all autocrine growth factor for hair dermal papilla cells
Vascular endothelial growth factor is all autocrine growth factor for hair dermal papilla cells
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DOI：
10.1111/1523-1747.ep12326964
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发表时间：
1996-01-01
影响因子：
6.5
通讯作者：
Plouet, J
中科院分区：
文献类型：
--
作者：
Lachgar, S;Moukadiri, H;Plouet, J
后期生长期到退化期阶段的过渡伴随着毛囊周围毛细血管的消失，因此周期性毛发生长可能取决于毛乳头向预先存在的毛细血管合成和释放可溶性生长和分化因子的能力。我们的特点是在毛乳头细胞的条件培养基中的血管生成生长因子与血管内皮生长因子难以区分的生物化学和免疫学标准判断，此外，这些细胞结合血管内皮。生长因子在两个结合位点上，并在该生长因子存在下增殖或迁移。此外，中和抗体抑制这些生物学效应，证实血管内皮生长因子可能通过直接作用于乳头细胞或刺激局部血管形成来促进毛发生长。
The transition of the late anagen to the catagen phase is concomitant with the disappearance of perifollicular capillaries, and therefore cyclical hair growth might depend on the ability of the dermal papilla to synthesize and release soluble growth and differentiation factors toward pre-existing capillaries. We characterized an angiogenic growth factor in the conditioned medium of dermal papilla cells indistinguishable from vascular endothelial growth factor as judged by biochemical and immunologic criteria, In addition, these cells bind vascular endothelial. growth factor on two binding sites and proliferate or migrate in the presence of this growth factor. Moreover, neutralizing antibodies inhibit these biologic effects, confirming that vascular endothelial growth factor might contribute to hair growth either by acting directly on papilla cells or by stimulating the local vascularization.