Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?
Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?
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DOI：
10.1186/s40695-018-0033-2
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Cedars, Marcelle I
中科院分区：
文献类型：
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作者：
Bleil, Maria E;English, Paul;Cedars, Marcelle I
BACKGROUND: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.METHODS: In a healthy, community-based sub-sample (n=350) of reproductive age participants in the OVA Study (2006-2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Prenatal maternal SES was assessed indirectly using maternal addresses abstracted from participant birth certificates, geocoded, and linked to US Census-derived variables, including neighborhood-level characteristics: education (% of individuals with a HS diploma); poverty (% of families below the poverty line); unemployment (% of individuals >16years who are unemployed); and income (median family income).RESULTS: In separate covariate-adjusted linear regression models (following the backward elimination of main effects with P>.10), greater maternal neighborhood education was related to higher ovarian reserve as marked by higher levels of offspring AMH (beta=.142, P
