Engineered Microvessels for the Study of Human Disease.
Engineered Microvessels for the Study of Human Disease.
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DOI：
10.1115/1.4034428
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
S. G. Rayner;Ying Zheng
中科院分区：
文献类型：
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作者：
S. G. Rayner;Ying Zheng
微血管系统是一个广泛、异质且复杂的系统，在人类生理和疾病中发挥着至关重要的作用。它滋养几乎所有活的人体细胞，并维持对组织和器官功能至关重要的局部微环境。微脉管系统在连续流动的状态下运行，尽管其口径较小，但其结构却很复杂，并且受到多种生物物理和生化刺激，因此微脉管系统可能是实验室环境中研究的复杂课题。工程微血管提供了一个理想的平台，可以概括体内生理学的基本要素，并允许以精确和可重复的方式研究微血管系统。在这里，我们回顾了相关的结构和功能血管生物学，讨论了设计微血管的不同方法，并探索了这一令人兴奋的工具在人类疾病研究中的应用。
The microvasculature is an extensive, heterogeneous, and complex system that plays a critical role in human physiology and disease. It nourishes almost all living human cells and maintains a local microenvironment that is vital for tissue and organ function. Operating under a state of continuous flow, with an intricate architecture despite its small caliber, and subject to a multitude of biophysical and biochemical stimuli, the microvasculature can be a complex subject to study in the laboratory setting. Engineered microvessels provide an ideal platform that recapitulates essential elements of in vivo physiology and allows study of the microvasculature in a precise and reproducible way. Here, we review relevant structural and functional vascular biology, discuss different methods to engineer microvessels, and explore the applications of this exciting tool for the study of human disease.