Correlative study of human papillomavirus DNA, histopathology and morphometry in cervical condyloma and intraepithelial neoplasia.
Correlative study of human papillomavirus DNA, histopathology and morphometry in cervical condyloma and intraepithelial neoplasia.
复制标题
宫颈尖锐湿疣和上皮内瘤变中人乳头瘤病毒DNA、组织病理学和形态学的相关性研究。
DOI：
10.1097/00004347-198812000-00001
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Orth,G
中科院分区：
文献类型：
--
作者：
Fu,YS;Huang,I;Beaudenon,S;Ionesco,M;Barrasso,R;deBrux,J;Orth,G
本研究包括28个宫颈上皮内鳞状病变与人乳头瘤病毒（HPV）DNA序列检测的Southern印迹技术。通过形态计量学参数和核分裂指数对组织学特征的客观分析表明，用逐步判别函数可将HPV 6型和11型与16型、18型和33型区分开来。后一种病变的有丝分裂指数和细胞构成指数较高，细胞核比前一种更大，支持与HPV 16/18/33型相关的更大程度的上皮增殖和异常。
This study includes 28 intraepithelial squamous lesions of the cervix associated with human papillomavirus (HPV) DNA sequences detected by the Southern blot technique. Objective analyses of the histologic features by mor-phometric parameters and mitotic index have demonstrated that lesions of HPV types 6 and 11 can be distinguished from types 16, 18, and 33 by stepwise discriminant functions. The latter lesions have higher mitotic and cellularity indexes and greater nuclear atypia than the former, supporting a greater degree of epithelial proliferation and abnormality seen in association with HPV types 16/18/33.