Gold Nanoparticle-Decorated g-C3N4 Nanosheets for Controlled Generation of Reactive Oxygen Species upon 670 nm Laser Illumination
Gold Nanoparticle-Decorated g-C3N4 Nanosheets for Controlled Generation of Reactive Oxygen Species upon 670 nm Laser Illumination
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金纳米粒子装饰的 g-C3N4 纳米片用于在 670 nm 激光照射下控制活性氧的产生
DOI：
10.1021/acsami.9b01307
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发表时间：
2019-03-20
影响因子：
9.5
通讯作者：
Yang, Huanghao
中科院分区：
文献类型：
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作者：
Dai, Jiayong;Song, Jibin;Yang, Huanghao
传统的基于光敏剂的光动力疗法是由紫外线照射触发的，依赖于氧气。然而，它很难应用于深部和低氧肿瘤。为了解决这一问题，我们报道了一种新的以金纳米粒子（AuNPs）修饰的g-C3N4纳米片，该纳米片在670 nm激光照射下在无氧环境下产生大量的活性氧（ROS）。所合成的半导体金属异质结作为一种优异的光动力剂，在670 nm光和g-C3N4-AuNP复合材料存在下表现出明显的癌细胞杀伤和肿瘤生长抑制作用，并通过进一步的杀菌实验验证了其优异的ROS生成性能。
Conventional photosensitizer-based photodynamic therapy is triggered by UV-light irradiation and depends on oxygen. However, it is hard to be applied to the deep and hypoxic tumor. To address this issue, we reported a new kind of g-C3N4 nanosheet decorated with gold nanoparticles (AuNPs), which could generate a high amount of reactive oxygen species (ROS) under a 670 nm laser irradiation in an oxygen-free environment. This synthesized semiconductor metal heterojunction served as a superior photodynamic agent, showing prominent cancer cell-killing and tumor growth-suppressing effects in the presence of a 670 nm light and g-C3N4-AuNP composites, and its excellent ROS generation property was also validated by further bactericidal experiment.