Development and consequences of cannabis dependence
Development and consequences of cannabis dependence
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DOI：
10.1002/j.1552-4604.2002.tb06000.x
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发表时间：
2002-11-01
影响因子：
2.9
通讯作者：
Moore, BA
中科院分区：
文献类型：
--
作者：
Budney, AJ;Moore, BA
经过10至15年的临床和基础研究，已经产生了强有力的证据，证明大麻能够而且确实产生了依赖性。临床和流行病学研究表明，大麻依赖是一种相对普遍的现象，与严重的心理社会损害有关。基础研究已经确定了大麻素作用的神经生物学系统。人类和非人类研究已经证明了一种有效的戒断综合征，这种综合征在重度大麻使用者中相对常见。最后，评估大麻依赖治疗的临床试验表明，这种疾病与其他物质依赖性疾病一样，对干预有反应，但大多数患者难以实现和维持禁欲。令人关切的是，在过去10年中，寻求大麻依赖治疗的人数几乎增加了两倍。本报告简要回顾了与我们目前对大麻依赖的理解相关的选定研究文献，其相关后果和治疗效果。临床药理学杂志，2002年。
The post 10 to 15 years of clinical and basic research have produced strong evidence demonstrating that cannabis can and does produce dependence. Clinical and epidemiological studies indicate that cannabis dependence is a relatively common phenomenon associated with significant psychosocial impairment. Basic research has identified a neurobiological system specific to the actions of cannabinoids. Human and nonhuman studies have demonstrated a valid withdrawal syndrome that is relatively common among heavy marijuana users. Last, clinical trials evaluating treatments for cannabis dependence suggest that this disorder, like other substance dependence disorders, is responsive to intervention, yet the majority of patients have difficulty achieving and maintaining abstinence. Of concern, treatment seeking for marijuana dependence has increased almost twofold over the past 10 years. This report briefly reviews selected research literature relevant to our current understanding of cannabis dependence, its associated consequences, and treatment efficacy. Journal of Clinical Pharmacology, 2002.