SPONTANEOUS CLIMBING BEHAVIOR OF MICE, ITS MEASUREMENT AND DOPAMINERGIC INVOLVEMENT
SPONTANEOUS CLIMBING BEHAVIOR OF MICE, ITS MEASUREMENT AND DOPAMINERGIC INVOLVEMENT
复制标题
DOI：
10.1016/0014-2999(82)90457-5
复制
发表时间：
1982-01-01
影响因子：
5
通讯作者：
NAYLOR, RJ
中科院分区：
文献类型：
--
作者：
COSTALL, B;ENIOJUKAN, JF;NAYLOR, RJ
小鼠自发攀爬行为的测量，在小鼠攀爬监视器中使用光电池检测垂直运动，当在40分钟内使用2只小鼠/笼子，并在1400小时前进行测量时，是最可靠和强烈的。攀爬反应被低剂量的神经抑制剂(-)-沙匹利和螺哌啶醇，以及低剂量的多巴胺激动剂阿波啡，n- n-丙基苯(f)喹啉，n-正丙基苯并(g)喹啉和2-二-正丙基氨基-5,6-二羟基四氢萘；N，N-二丙基多巴胺效果较差。高剂量的多巴胺激动剂诱导攀爬。阿波啡的抑制作用被(-)-舒必利和螺哌啶醇部分拮抗（剂量本身不改变自发攀爬），但吡唑嗪或育亨宾不起作用。双侧尾壳核、伏隔核或嗅结核电损伤在术后最初5-9天内减弱自发攀爬，伏隔核电损伤最有效。小鼠的自发攀爬行为可以被精确地量化，其表达与含多巴胺的前脑区域有关，并且可以被多巴胺激动剂和拮抗剂有效地修饰。
Measurement of spontaneous climbing behavior of mice, made in Mouse Climbing Monitors which used photo cell detection of vertical movements, was most reliable and intense when made over a 40-min period using 2 mice/cage and taking readings before 1400 h. The climbing response was antagonized by low doses of the neuroleptics (-)-sulpiride and spiroperidol, and by low doses of the dopamine agonists apomorphine, N-n-propylbenzo(f)quinoline, N-n-propylbenzo(g)quinoline and 2-di-n-propylamino-5,6-dihydroxytetralin; N,N-dipropyldopamine was less effective. Higher doses of the dopamine agonists induced climbing. The inhibition afforded by apomorphine was partially antagonized by (-)-sulpiride and spiroperidol (at doses which do not in themselves modify spontaneous climbing) but not by prazosin or yohimbine. Bilateral electrolesions of the caudate-putamen, nucleus accumbens or tuberculum olfactorium attentuated spontaneous climbing for the first 5-9 postoperative days, the accumbens lesions being most effective. Spontaneous climbing behavior of mice can be precisely quantified, dopamine-containing forebrain areas are involved with its expression, and it can be potently modified by dopamine agonists and antagonists.