Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.
Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.
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DOI：
10.2147/copd.s2089
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发表时间：
2008
影响因子：
2.8
通讯作者：
Owen CA
中科院分区：
文献类型：
--
作者：
Owen CA
自20世纪60年代初以来，大量证据表明蛋白酶在慢性阻塞性肺疾病（COPD）的气道扩大中起着关键作用。然而，直到最近，致病酶及其在COPD病理过程中的确切作用尚不清楚。最近在COPD小鼠模型中对基因靶向小鼠的研究证实了蛋白酶不仅在气道扩大中，而且在COPD的气道病理中的作用。这些研究还揭示了参与COPD发病机制的特定蛋白酶，以及这些蛋白酶损伤肺的机制。他们还确定了不同类型的蛋白酶之间的重要相互作用，以及蛋白酶与其他放大肺部炎症和损伤的分子之间的相互作用。本文将讨论蛋白酶的生物学及其在COPD发病机制中的作用。此外，我将讨论蛋白酶抑制剂和抗炎药物作为COPD患者新治疗策略的潜力。
Since the early 1960s, a compelling body of evidence has accumulated to show that proteinases play critical roles in airspace enlargement in chronic obstructive pulmonary disease (COPD). However, until recently the causative enzymes and their exact roles in pathologic processes in COPD have not been clear. Recent studies of gene-targeted mice in murine models of COPD have confirmed roles for proteinases not only in airspace enlargement, but also in airway pathologies in COPD. These studies have also shed light on the specific proteinases involved in COPD pathogenesis, and the mechanisms by which these proteinases injure the lung. They have also identified important interactions between different classes of proteinases, and between proteinases and other molecules that amplify lung inflammation and injury. This review will discuss the biology of proteinases and the mechanisms by which they contribute to the pathogenesis of COPD. In addition, I will discuss the potential of proteinase inhibitors and anti-inflammatory drugs as new treatment strategies for COPD patients.