Blood to brain transport of interleukin links the immune and central nervous systems.
Blood to brain transport of interleukin links the immune and central nervous systems.
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DOI：
10.1016/0024-3205(91)90385-o
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
Kastin, A J
中科院分区：
文献类型：
--
作者：
Banks, W A;Kastin, A J
白细胞介素（IL）是天然存在的蛋白质，其调节并因此连接免疫系统和中枢神经系统（CNS）。由于蛋白质被认为不能穿过血脑屏障（BBB），因此这种联系如何发生仍有争议。我们在此显示，静脉注射125 I-hIL-1 α后，在HPLC上标记细胞因子的位置洗脱脑中的放射性。此外，未标记的hIL-1 α抑制进入。我们证明了一个可饱和的载体介导的系统，该系统将重组人IL-1 α以完整的形式从血液转运到CNS中，这表明了直接的免疫-CNS连接。
Interleukins (IL) are naturally occurring proteins that regulate, and thus link, both the immune system and the central nervous system (CNS). Since proteins are assumed not to be able to cross the blood-brain barrier (BBB), it is controversial how this linkage could occur. We show here that after iv injection of 125I-hIL-1 alpha, radioactivity in the brain eluted on HPLC in the position of the labeled cytokine. In addition, entry was inhibited by unlabeled hIL-1 alpha. Our demonstration of a saturable, carrier-mediated system that transports recombinant human IL-1 alpha in intact form from the blood into the CNS indicates a direct immune-CNS connection.