Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes.
Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes.
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DOI：
10.1289/ehp.0800247
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
Zoeller RT
中科院分区：
文献类型：
--
作者：
Miller MD;Crofton KM;Rice DC;Zoeller RT
在人类和实验动物中有越来越多的证据表明，暴露于特定环境化学品与至关重要的甲状腺激素水平的扰动之间存在关系。为了准确评估公共卫生风险，需要确定和正确解释这些关系。我们回顾TH在神经系统发育和特定结果中的作用，在成人，外源性物质对甲状腺信号的影响，甲状腺破坏和上游因果生物标志物的不良后果之间的关系，以及外源性化学物质干扰甲状腺信号的社会影响。我们利用了广泛的流行病学、毒理学和机理研究。TH对正常神经系统发育至关重要，母亲TH水平降低与儿童神经心理发育不良有关。在成年人中，促甲状腺激素增加与血压升高和血脂水平降低有关，这两者都是心血管疾病和死亡的危险因素。即使在人群的“正常”范围内也观察到甲状腺抑制的这些影响。环境化学物质可能通过多种机制影响甲状腺稳态，并且已确定多种化学物质通过每种已确定的机制干扰甲状腺功能。个人由于接触干扰甲状腺的化学品而可能容易受到不利影响。任何程度的甲状腺破坏，影响TH水平的人口基础上应被视为一个生物标志物的不良后果，这可能有重要的社会后果。
There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health. We review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals. We drew on an extensive body of epidemiologic, toxicologic, and mechanistic studies. THs are critical for normal nervous system development, and decreased maternal TH levels are associated with adverse neuropsychological development in children. In adult humans, increased thyroid-stimulating hormone is associated with increased blood pressure and poorer blood lipid profiles, both risk factors for cardiovascular disease and death. These effects of thyroid suppression are observed even within the “normal” range for the population. Environmental chemicals may affect thyroid homeostasis by a number of mechanisms, and multiple chemicals have been identified that interfere with thyroid function by each of the identified mechanisms. Individuals are potentially vulnerable to adverse effects as a consequence of exposure to thyroid-disrupting chemicals. Any degree of thyroid disruption that affects TH levels on a population basis should be considered a biomarker of adverse outcomes, which may have important societal outcomes.
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影响因子：
10.4
作者：
Crofton KM;Craft ES;Hedge JM;Gennings C;Simmons JE;Carchman RA;Carter WH Jr;DeVito MJ
通讯作者：
DeVito MJ
影响因子：
2.8
作者：
Crofton, KM;Ding, DL;Henderson, D
通讯作者：
Henderson, D
影响因子：
4.8
作者：
Ausó, E;Lavado-Autric, R;Berbel, P
通讯作者：
Berbel, P
影响因子：
6.6
作者：
Andersen, S;Bruun, NH;Laurberg, P
通讯作者：
Laurberg, P
影响因子：
--
作者：
Crofton, Kevin M.
通讯作者：
Crofton, Kevin M.