Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight.
Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight.
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DOI：
10.1093/aje/kww213
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发表时间：
2017-02-01
影响因子：
5
通讯作者：
Platt RW
中科院分区：
文献类型：
--
作者：
Ashley-Martin J;Dodds L;Arbuckle TE;Bouchard MF;Fisher M;Morriset AS;Monnier P;Shapiro GD;Ettinger AS;Dallaire R;Taback S;Fraser W;Platt RW
全氟烷基物质(PFAS)是一种普遍存在的持久性化学物质，因其不可燃、疏油和疏水特性而被广泛应用于普通家用和消费品的生产中。母亲或脐带血中全氟辛酸和全氟辛烷磺酸的浓度与出生体重之间的负相关已被确认。这篇文献主要是单独研究每种全氟辛烷磺酸，而没有考虑相关暴露的潜在影响。此外，PFAS暴露与代谢功能指标(即瘦素和脂联素)之间的联系受到的关注有限。我们利用母婴环境化学研究(MIREC)研究的1705对母婴数据，检验了怀孕早期孕妇血浆PFAS浓度与出生体重和脐带血瘦素和脂联素浓度的关系。MIREC研究是一项跨加拿大出生队列研究，在2008至2011年间招募了女性。贝叶斯层次模型被用来量化关联度和计算可信区间。母体全氟辛酸浓度与出生体重z得分呈负相关，尽管在所有可信区间中都包含了空值(log10β=−0.10，95%可信区间：−0.34，0.13)。孕妇的PFAS浓度和脐血脂肪细胞因子浓度之间的所有关联都是小幅度的，并且集中在零值附近。需要对一组儿童进行跟踪，以确定观察到的关联在儿童时期是如何表现出来的。
Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfluorooctanesulfonate and birth weight have been identified. This literature has primarily examined each PFAS individually without consideration of the potential influence of correlated exposures. Further, the association between PFAS exposures and indicators of metabolic function (i.e., leptin and adiponectin) has received limited attention. We examined associations between first-trimester maternal plasma PFAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using data on 1,705 mother-infant pairs from the Maternal Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada birth cohort study that recruited women between 2008 and 2011. Bayesian hierarchical models were used to quantify associations and calculate credible intervals. Maternal perfluorooctanoic acid concentrations were inversely associated with birth weight z score, though the null value was included in all credible intervals (log10 β = −0.10, 95% credible interval: −0.34, 0.13). All associations between maternal PFAS concentrations and cord blood adipocytokine concentrations were of small magnitude and centered around the null value. Follow-up in a cohort of children is required to determine how the observed associations manifest in childhood.