Insight of Lectins- A review
Insight of Lectins- A review
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凝集素的见解 - 回顾
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Sarathi
中科院分区：
文献类型：
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作者：
Himansha Singh;S. Sarathi
凝集素是一种碳水化合物结合蛋白，以其毒性相关而闻名。历史为它们的毒性特征提供了各种证据，最初，人们认为凝集素只与有毒成分有关。然而，最近的研究表明，凝集素科学有了显著的发展，并在研究糖蛋白的生物合成、研究细胞/细胞器上的碳水化合物、绘制神经元通路、抗癌治疗以及在淋巴细胞的有丝分裂刺激中的应用得到了很好的证明。尽管凝集素引起了当前研究人员对其治疗价值的研究，但到目前为止还没有进行足够的研究，关于凝集素的知识仅限于某些植物或动物来源，进一步的研究对于确定凝集素及其在尽可能多来源中的重要性是重要的。本文从凝集素的最初发现、纯化、生物学作用等方面综述了凝集素的研究进展，并概述了凝集素的毒理作用和治疗作用。在寻找它们的功能时，终点可能看不到，但最终可以想象，它就在角落里。如果对凝集素的理解做出有效的研究，凝集素可能成为下一代药物。
Lectins are the carbohydrate-binding proteins and are known for their toxic relevance. History provides various evidences for their toxicity profile and initially, it was thought that lectins are associated solely with toxic content. However, recent research shows a remarkable development in lectin science and their use in studying glycoprotein biosynthesis, investigating carbohydrates on cells/cellorganelles, mapping neuronal pathways, anti-cancer therapies and in mitogenic stimulation of lymphocytes is well documented. Even though lectins have intrigued current researchers for the investigation of their therapeutic values, not enough studies have been conducted so far and knowledge about lectins is limited to certain plants or animal sources and further research is important to identify lectins and their importance in as many sources as possible. This review is a comprehensive account of lectins starting from their initial discovery, their purification, biological role and also presents an outline of their toxic effects and therapeutic contribution. In the search for their functions, the end may not be in sight but, at last, it is conceivably around the corner. Lectins could be the next generation medicines if efficient research is contributed in their understanding.
基于 GaN 量子阱的 249 nm 深紫外激光器
影响因子：
7
作者：
Shan, Maocheng;Zhang, Yi;Li, Xiaohang
通讯作者：
Li, Xiaohang