Total synthesis of strictamine: a tutorial for novel and efficient synthesis
Total synthesis of strictamine: a tutorial for novel and efficient synthesis
复制标题
严格胺的全合成：新型高效合成教程
DOI：
10.1039/c7qo00837f
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发表时间：
2018
影响因子：
5.4
通讯作者：
Hong Ran
中科院分区：
文献类型：
--
作者：
Wang Chao;Zhang Shiju;Wang Yan;Huang Sha-Hua;Hong Ran
在课堂上教授合成设计时，整个合成路线的新颖性和效率是向年轻一代合成化学家传授的关键价值观。创造性的综合设计对于第一次进入这个令人兴奋的领域的研究生来说非常感兴趣。严格胺是一种阿库氨碱生物碱，具有密集的笼状结构，具有有趣的生物活性。自五年前发现该化合物以来，人们对该化合物的全合成进行了许多尝试。直到去年合成化学家开始应用新颖的环构建策略时，合成才完成。 2016年，两个研究小组报道了严格胺的全合成，四个研究小组报道了正式合成。在这个亮点中，严格胺的合成被用作教程案例来说明全合成的新颖性和效率。
When teaching synthetic design in the classroom, the novelty and efficiency of the overall synthetic route are the key values being imparted to the younger generation of synthetic chemists. The creative synthetic design is of great interest to graduate students who are entering into this exciting field for the first time. Strictamine, an akuammiline alkaloid, bears a congested cage-like structure and has interesting biological activities. Numerous attempts have been made toward the total synthesis of this compound since its discovery five decades ago. The synthesis was not completed until last year when synthetic chemists began to apply novel ring construction strategies. In 2016, two research groups reported the total syntheses of strictamine and four reported the formal syntheses. In this Highlight, the synthesis of strictamine is used as a tutorial case to illustrate novelty and efficiency in total synthesis.