Transformation of Tetracyclines Mediated by Mn(II) and Cu(II) Ions in the Presence of Oxygen
Transformation of Tetracyclines Mediated by Mn(II) and Cu(II) Ions in the Presence of Oxygen
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DOI：
10.1021/es802295r
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发表时间：
2009-01-15
影响因子：
11.4
通讯作者：
Huang, Ching-Hua
中科院分区：
文献类型：
--
作者：
Chen, Wan-Ru;Huang, Ching-Hua
四环素（TC）与溶解的Mn-II和Cull离子的络合被发现分别在pH 8-9.5和pH 4-6的氧气存在下显著增强这些抗生素的转化。在TC-Mn-II-O-2体系中，TC络合的Mn-II被氧气氧化为Mn-III，随后TC被Mn-III氧化以再生Mn-II。在TC-Cu”-02体系中，Cu-II氧化络合物内的TC，并且产生的Cu-I被存在的氧再氧化。观察到两种金属的相反反应性趋势：对于Mn-II介导的反应，OTC（土霉素）> TTC（四环素）>>异CTC（异金霉素），而对于Cu-II介导的反应，CTC > TTC > OTC >差向异构体。TC-金属离子络合和转化产物的反应性结果和检测表明，TC的BCD环和A环分别对与Mn-II和Cu-II的相互作用至关重要。这项研究强调，在水生环境中的TC的命运可能会有显着不同的强相互作用与不同的金属物种存在于系统中。
Complexation of tetracyclines (TCs) with dissolved Mn-II and Cull ions were found to significantly enhance the transformation of these antibiotics in the presence of oxygen at pH 8-9.5 and pH 4-6, respectively. In the TC-Mn-II-O-2 system, oxidation of the TC-complexed Mn-II to Mn-III by oxygen occurs, followed by oxidation of TC by Mn-III to regenerate Mn-II. In the TC-CU"-02 system, Cu-II oxidizes TC within the complex and the yielded Cu-I is reoxidized by the present oxygen. Opposite reactivity trends were observed with the two metals: OTC (oxytetracycline) > TTC (tetracycline) >> iso-CTC (isochlorotetracycline) for the Mn-II-mediated reaction, whereas CTC > TTC > OTC > epimers for the Cu-II-mediated reaction. The reactivity results and examination of TC-metal ion complexation and transformation products suggest that the BCD-ring and A-ring of TC are crucial to interactwith Mn-II and Cu-II, respectively. This study highlights that the fate of TCs in aquatic environments may differ significantly by their strong interactions with different metal species present in the systems.