FMRI as a measure of cognition related brain circuitry in schizophrenia.
FMRI as a measure of cognition related brain circuitry in schizophrenia.
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DOI：
10.1007/7854_2011_173
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发表时间：
2012
影响因子：
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通讯作者：
Ragland, J Daniel
中科院分区：
文献类型：
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作者：
Libby, Laura A;Ragland, J Daniel
功能磁共振成像（fMRI）在寻找导致精神分裂症认知功能障碍的大脑系统方面发挥了重要作用。本章描述了这些研究工作的演变，这些研究工作在定位特定认知障碍的工作和试图理解更广泛的网络功能障碍的工作之间交替进行。在简要总结本地化工作之后，本章的其余部分描述了不同的科学家群体如何开发和测试更广泛的网络理论。这包括对任务激活和静息状态研究的描述，并涉及广泛的分析技术。本章最后介绍了当前的默认模式和任务正向网络理论如何从这些早期的静息状态和任务激活方法中发展而来，并提供了一些关于未来方向的建议。
Functional magnetic resonance imaging (fMRI) has played a prominent role in the quest to identify the brain systems responsible for cognitive dysfunction in schizophrenia. This chapter describes the evolution of these research efforts, which have alternated between efforts to localize specific cognitive impairments to work trying to understand broader network dysfunction. After a concise summary of localization efforts, the remainder of the chapter describes how different groups of scientists have developed and tested broader network theories. This includes a description of both task-activation and resting state studies, and involves a wide array of analytic techniques. The chapter closes with an understanding of how current default-mode and task-positive network theories grew out of these earlier resting-state and task-activation approaches, and provides some recommendations about future directions.