Biofilms in Chronic Wounds and the Potential Role of Negative Pressure Wound Therapy
Biofilms in Chronic Wounds and the Potential Role of Negative Pressure Wound Therapy
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DOI：
10.1097/won.0b013e31827e8481
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发表时间：
2013-03-01
影响因子：
2.6
通讯作者：
Cunningham, Muriel
中科院分区：
文献类型：
--
作者：
Bradley, Beth Hawkins;Cunningham, Muriel
Biofilms are communities of microbes that exist in a variety of environments. The extracellular substances secreted by biofilms make them difficult to eradicate, giving the bacterial community in the biofilm a resistance advantage over freefloating (planktonic) microbes. Biofilms are particularly problematic in chronic wounds because of their resistance to conventional therapies and tendency to delay healing. Multimodal strategies to combat wound biofilms are necessary, including wound debridement, antimicrobial treatment, and continued disruption of biofilms. Negative pressure wound therapy with irrigation or instillation may lower the bacterial burden in chronic wounds and prevent the biofilm formation. This article provides an overview of biofilms and evolving strategies to counteract them.
