Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: Diffuse and sustained.
Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: Diffuse and sustained.
复制标题
脑小血管疾病中动态脑自动调节的特征：弥漫性和持续性。
DOI：
10.1038/srep15269
复制
发表时间：
2015-10-15
影响因子：
4.6
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Guo ZN;Xing Y;Wang S;Ma H;Liu J;Yang Y
脑小血管疾病是中风和血管性痴呆的主要原因，然而，其发病机制在很大程度上尚不清楚。本研究旨在探讨腔隙性脑梗死患者动态脑自动调节功能（dCA）受损的特点。71例腔隙性脑梗死患者入组该研究，其中包括46例单侧大脑中动脉（MCA）区域中风患者和25例单侧大脑后动脉（PCA）区域中风患者。每组患者随机分为两个亚组。第1组在双侧MCA中进行dCA评估，第2组在双侧PCA中进行dCA评估。术后随访6个月。采用传递函数分析法推导了增益和相位差的自动调节参数。在单侧MCA区卒中患者中，MCA和PCA均观察到dCA损伤，并且在单侧PCA区卒中患者中观察到相同的结果。这些损伤在6个月随访期间保持不变。腔隙性脑梗死是最常见的脑小血管病类型，即使单侧MCA区/PCA区卒中，dCA的损害也是全面的和持续的。这一发现表明，与腔隙性梗死相关的生理变化是弥漫性的。
Cerebral small vessel disease is a major cause of stroke and vascular dementia; however, the pathogenesis is largely unclear. In this study, we investigated the characteristics of the impairment of dynamic cerebral autoregulation (dCA) in lacunar infarction patients. Seventy-one lacunar infarction patients were enrolled in the study, including 46 unilateral middle cerebral artery (MCA) territory stroke patients and 25 unilateral posterior cerebral artery (PCA) territory stroke patients. Each group of patients was randomly divided into two subgroups. Group 1 underwent dCA assessments in the bilateral MCAs, and Group 2 underwent dCA assessments in the bilateral PCAs. All patients were followed up for 6 months. Transfer function analysis was applied to derive the autoregulatory parameters of gain and phase difference. In the unilateral MCA territory stroke patients, impairments of dCA were observed in both the MCAs and PCAs, and the same results were observed in the unilateral PCA territory stroke patients. These impairments remained unchanged during the 6-month follow-up. In lacunar infarction, which is most prevalent type of cerebral small vessel disease, though patients with unilateral MCA territory/PCA territory stroke, the impairments of dCA were global and sustained. This finding suggests that the physiological changes associated with lacunar infarction were diffuse.