ONE-DIMENSIONAL SIMULATION OF AEROSOL TRANSPORT AND DEPOSITION IN THE HUMAN LUNG
ONE-DIMENSIONAL SIMULATION OF AEROSOL TRANSPORT AND DEPOSITION IN THE HUMAN LUNG
复制标题
DOI：
10.1152/jappl.1994.77.6.2889
复制
发表时间：
1994-12-01
影响因子：
3.3
通讯作者：
PAIVA, M
中科院分区：
文献类型：
--
作者：
DARQUENNE, C;PAIVA, M
一维传输模型（喇叭模型和多分支点模型）源自为研究肺部气体传输和混合而开发的模型，用于模拟气溶胶沉积，作为人肺中吸入团剂的粒径和气溶胶分散的函数。与之前的研究一致，不同模型对气溶胶沉积的模拟令人满意。然而，气溶胶团剂分散的模拟和实验之间的差异表明当前模型并不现实。这可能是由于描述肺外周气溶胶输送的一维模型的内在局限性。我们表明，未来的模型分析可能可以使用对称的腺泡结构，如经典的肺韦贝尔模型，但需要多维粒子传输方程。此外，还需要对口喉路径中的气溶胶分散进行严格的描述。
One-dimensional transport models (trumpet model and multibranch-point model) derived from those developed to study gas transport and mixing in the lung are used to simulate aerosol deposition as a function of particle diameter and aerosol dispersion of inhaled bolus in human lungs. In agreement with previous studies, aerosol deposition is satisfactorily simulated by the different models. However, the differences between simulations and experiments of aerosol bolus dispersion suggest that current models are not realistic. This is probably due to the intrinsic limitations of the one-dimensional models to describe aerosol transport in the lung periphery. We show that future model analyses can probably use a symmetric acinar structure like the classic Weibel model of the lung but that multidimensional particle transport equations are required. Furthermore, a rigorous description of aerosol dispersion in the oral-laryngeal path is also needed.