Emerging role of circulating tumor cells in immunotherapy.
Emerging role of circulating tumor cells in immunotherapy.
复制标题
循环肿瘤细胞在免疫治疗中的新作用。
DOI：
10.7150/thno.59677
复制
发表时间：
2021
期刊：
影响因子：
12.4
通讯作者：
Ebrahimi Warkiani M
中科院分区：
文献类型：
--
作者：
Rzhevskiy A;Kapitannikova A;Malinina P;Volovetsky A;Aboulkheyr Es H;Kulasinghe A;Thiery JP;Maslennikova A;Zvyagin AV;Ebrahimi Warkiani M
在过去的几年里，免疫疗法，特别是免疫检查点抑制剂疗法，已经彻底改变了几种类型癌症的治疗。与此同时，由于治疗费用高、相关毒性概况和患者对治疗反应的差异，临床肿瘤学的吸收一直缓慢。因此，基于预测性生物标志物的个性化方法已成为患者分层以实现有效免疫治疗的新工具。近年来，循环肿瘤细胞（CTCs）的计数和分子分析已成为癌症患者化疗期间管理和个性化靶向治疗的预后生物标志物。免疫检查点在ctc上的表达已经在许多实体肿瘤类型中得到报道，并为癌症免疫治疗管理提供了新的见解。在这篇综述中，我们讨论了使用CTCs识别免疫检查点的最新进展，并阐明了CTCs在识别免疫治疗预测性生物标志物方面的潜在应用。
Over the last few years, immunotherapy, in particular, immune checkpoint inhibitor therapy, has revolutionized the treatment of several types of cancer. At the same time, the uptake in clinical oncology has been slow owing to the high cost of treatment, associated toxicity profiles and variability of the response to treatment between patients. In response, personalized approaches based on predictive biomarkers have emerged as new tools for patient stratification to achieve effective immunotherapy. Recently, the enumeration and molecular analysis of circulating tumor cells (CTCs) have been highlighted as prognostic biomarkers for the management of cancer patients during chemotherapy and for targeted therapy in a personalized manner. The expression of immune checkpoints on CTCs has been reported in a number of solid tumor types and has provided new insight into cancer immunotherapy management. In this review, we discuss recent advances in the identification of immune checkpoints using CTCs and shed light on the potential applications of CTCs towards the identification of predictive biomarkers for immunotherapy.