Modification of acute murine cytomegalovirus adrenal gland infection by adoptive spleen cell transfer.
Modification of acute murine cytomegalovirus adrenal gland infection by adoptive spleen cell transfer.
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通过过继脾细胞移植改变急性小鼠巨细胞病毒肾上腺感染。
DOI：
10.1128/jvi.61.1.23-28.1987
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发表时间：
1987
影响因子：
5.4
通讯作者：
Shanley,JD
中科院分区：
文献类型：
--
作者：
Shanley,JD
感染鼠巨细胞病毒（MCMV）的纯合子（nu/nu）无胸腺裸鼠，可发生累及肾上腺皮质和髓质的持续性和消融性病毒感染。在急性感染期间，过继转移MCMV免疫脾细胞而非幼稚脾细胞抑制肾上腺中的病毒复制，但不抑制肺或唾液腺中的病毒复制。限制病毒复制的是T淋巴细胞，而不是巨噬细胞或B细胞。供体细胞的作用受主要组织相容性位点的相容性限制。肾上腺中MCMV复制的限制与L3 T4表型的T淋巴细胞相关。因此，T细胞免疫在调节肾上腺中MCMV复制中至关重要，并且受II类主要组织相容性抗原限制的T淋巴细胞介导这种作用。
Homozygous (nu/nu), athymic nude mice, infected with murine cytomegalovirus (MCMV), develop unremitting and ablative virus infection involving both the adrenal cortex and medulla. During acute infection, adoptive transfer of MCMV-immune, but not naive, spleen cells suppressed virus replication in the adrenal glands, but not the lungs or salivary gland. T lymphocytes, not macrophages or B cells, were responsible for limiting viral replication. The effect by donor cells was restricted by compatibility at the major histocompatibility locus. Restriction of MCMV replication in the adrenal gland was associated with T lymphocytes of the L3T4 phenotype. Thus, T-cell immunity is critical in regulating MCMV replication in the adrenal glands, and T lymphocytes restricted by class II major histocompatibility antigens mediate this effect.