Influence of CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Expression on the Survival of Patients with Non-Metastatic Nasopharyngeal Carcinoma.
Influence of CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Expression on the Survival of Patients with Non-Metastatic Nasopharyngeal Carcinoma.
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DOI：
10.2147/cmar.s314925
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发表时间：
2021
影响因子：
3.3
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Li Z;Zhao Y
本研究旨在探讨CDK 5调节亚基相关蛋白1样1（CDKAL 1）表达对鼻咽癌患者生存期的影响。回顾性分析了140例非转移性NPC患者。免疫组化法检测CDKAL 1的表达。根据Kaplan-Meier曲线分析（p = 0.006），CDKAL 1阴性组的总生存期（OS）较好，CDKAL 1阴性组和CDKAL 1阳性组的5年OS率分别为89.7%和70.2%。CDKAL 1阴性组也表现出更好的无进展生存率（PFS）趋势。多变量分析显示，CDKAL 1表达与OS（p = 0.002）和PFS（p = 0.043）独立相关。CDKAL 1表达是非转移性NPC患者生存的独立负性预测因子。
The aim of this study was to investigate the influence of CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) expression on the survival of nasopharyngeal carcinoma (NPC) patients. A total of 140 non-metastatic NPC patients were retrospectively analyzed. The expression of CDKAL1 was detected by immunohistochemistry. The CDKAL1-negative group exhibited better overall survival (OS) according to Kaplan–Meier curve analysis (p = 0.006), with 5-year OS rates for the CDKAL1-negative and -positive groups of 89.7% and 70.2%, respectively. The CDKAL1-negative group also exhibited a tendency toward a better progression-free survival (PFS) rate. Multivariate analysis showed that CDKAL1 expression was independently associated with both OS (p = 0.002) and PFS (p = 0.043). CDKAL1 expression is an independent negative predictor of patient survival in non-metastatic NPC.