Wound healing and local neuroendocrine regulation in the injured liver
Wound healing and local neuroendocrine regulation in the injured liver
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DOI：
10.1017/s146239940800063x
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发表时间：
2008-04-29
影响因子：
6.2
通讯作者：
Mann, Derek A.
中科院分区：
文献类型：
--
作者：
Ebrahimkhani, Mohammad R.;Elsharkawy, Ahmed M.;Mann, Derek A.
肝脏伤口愈合反应是一个复杂的过程，涉及许多不同的细胞类型和因素。它导致形成过多的基质和纤维化疤痕，最终破坏肝脏的正常功能并形成肝硬化。源自肝星状细胞（HSC）等细胞的活化的肝肌成纤维细胞在此过程中发挥着关键作用。慢性肝损伤后，局部神经内分泌系统会出现上调，最近已证明活化的 HSC 表达特定受体并对该系统的不同成分做出反应。神经内分泌因子及其受体参与调节肝脏炎症和伤口愈合的复杂网络，并控制肝纤维化的发生和进展。本综述的第一部分概述了控制肝脏伤口愈合的分子机制。在第二部分中，我们探讨了肝神经内分泌系统的重要组成部分及其最近在 HSC 生物学和肝纤维发生中突出的作用。我们讨论正在开发的用于抗纤维化治疗的治疗干预措施。
The hepatic wound-healing response is a complex process involving many different cell types and factors. It leads to the formation of excessive matrix and a fibrotic scar, which ultimately disrupts proper functioning of the liver and establishes cirrhosis. Activated hepatic myofibroblasts, which are derived from cells such as hepatic stellate cells (HSCs), play a key role in this process. Upon chronic liver injury, there is an upregulation in the local neuroendocrine system and it has recently been demonstrated that activated HSCs express specific receptors and respond to different components of this system. Neuroendocrine factors and their receptors participate in a complex network that modulates liver inflammation and wound healing, and controls the development and progression of liver fibrosis. The first part of this review provides an overview of the molecular mechanisms governing hepatic wound healing. In the second section, we explore important components of the hepatic neuroendocrine system and their recently highlighted roles in HSC biology and hepatic fibrogenesis. We discuss the therapeutic interventions that are being developed for use in antifibrotic therapy.