TWITCHES IN PRESENCE OF ETHYLENE-GLYCOL BIS(BETA-AMINOETHYL ETHER)-N,N'-TETRAACETIC ACID
TWITCHES IN PRESENCE OF ETHYLENE-GLYCOL BIS(BETA-AMINOETHYL ETHER)-N,N'-TETRAACETIC ACID
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DOI：
10.1016/0005-2728(72)90194-6
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
HOROWICZ, P
中科院分区：
文献类型：
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作者：
ARMSTRONG, CM;BEZANILLA, FM;HOROWICZ, P
当浸泡在含有少于10−8M游离钙的乙二醇双（β-氨基乙醚）-N,N ' -四乙酸（EGTA）溶液中时，单个肌肉纤维继续抽搐长达20分钟。抽搐失败的原因是可逆去极化，发生在EGTA 15-20分钟后。结果表明，外钙或横小管内的钙在动作电位的传播或兴奋-收缩耦合中起不重要的作用。
Single muscle fibers continue to twitch for up to 20 min when immersed in ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA) solutions containing less than 10−8M free calcium. Failure of the twitch results from reversible depolarization, which occurs after 15–20 min in EGTA. The results make it clear that external calcium or calcium in the transverse tubules play no essential part in action potential propagation or excitation-contraction coupling.