The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor.
The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor.
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DOI：
10.3390/ijms19020546
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发表时间：
2018-02-11
影响因子：
5.6
通讯作者：
Vaidya A
中科院分区：
文献类型：
--
作者：
Baudrand R;Vaidya A
相当比例的高血压患者存在低肾素或抑制肾素。这种低肾素高血压（LRH）的表型可能是遗传综合征、获得性体细胞突变或环境暴露的表现。矿物皮质激素受体的激活是LRH发展的共同最终机制。传统上，LRH的个体病因被认为是罕见的疾病；然而，最近的进展表明，许多lrh诱导条件存在较温和的“非经典”变体。在这方面，我们对LRH的潜在遗传学和机制的理解正在不断发展，因此，原发性高血压的潜在发病机制也在不断发展。这篇综述将讨论LRH的潜在原因，重点是相关的遗传机制，对诱导LRH的非经典变异的不断扩大的认识，以及矿皮质激素受体在决定这种表型中的作用。
A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and “non-classical” variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.
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DOI：
10.1210/jc.2011-1565
发表时间：
2011-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Arlt W;Biehl M;Taylor AE;Hahner S;Libé R;Hughes BA;Schneider P;Smith DJ;Stiekema H;Krone N;Porfiri E;Opocher G;Bertherat J;Mantero F;Allolio B;Terzolo M;Nightingale P;Shackleton CH;Bertagna X;Fassnacht M;Stewart PM
通讯作者：
Stewart PM
DOI：
10.1161/hypertensionaha.116.08952
发表时间：
2017-05
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Baudrand R;Guarda FJ;Fardella C;Hundemer G;Brown J;Williams G;Vaidya A
通讯作者：
Vaidya A
影响因子：
39.2
作者：
Brown JM;Robinson-Cohen C;Luque-Fernandez MA;Allison MA;Baudrand R;Ix JH;Kestenbaum B;de Boer IH;Vaidya A
通讯作者：
Vaidya A
影响因子：
3.7
作者：
Bouligand J;Delemer B;Hecart AC;Meduri G;Viengchareun S;Amazit L;Trabado S;Fève B;Guiochon-Mantel A;Young J;Lombès M
通讯作者：
Lombès M
DOI：
10.1126/science.1198785
发表时间：
2011-02-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choi M;Scholl UI;Yue P;Björklund P;Zhao B;Nelson-Williams C;Ji W;Cho Y;Patel A;Men CJ;Lolis E;Wisgerhof MV;Geller DS;Mane S;Hellman P;Westin G;Åkerström G;Wang W;Carling T;Lifton RP
通讯作者：
Lifton RP