A translational pause tolocalize
A translational pause tolocalize
复制标题
翻译暂停以进行本地化
作者：
Ron;D. and Ito;K.
信使RNA(MRNA)的非传统剪接是控制细胞对内质网(ER)中积累的未折叠蛋白质的反应的关键。哺乳动物细胞试图通过转录因子XBP1表达特定基因来抵消这种应激状态。这种转录因子的合成需要剪接来产生其编码的mRNA，这一过程发生在ER膜的细胞质表面。在本期的第586页上，Yanagitaniet等人揭示了要剪接的mRNA的翻译暂停是如何有助于这种定位的。这一发现揭示了真核生物和原核生物在调控翻译的机制上惊人的相似之处。
The unconventional splicing of a messenger RNA (mRNA) is key to a mechanism that controls the cellular response to unfolded proteins that accumulate in the endoplasmic reticulum (ER). Mammalian cells attempt to counterbalance this state of stress by expressing specific genes through the transcription factor XBP1 . The synthesis of this transcription factor requires splicing to generate its encoding mRNA, a process that occurs at the cytoplasmic face of the ER membrane. On page 586 of this issue , Yanagitaniet al.reveal how translational pausing of the mRNA to be spliced contributes to this localization. The finding reveals surprising similarities in mechanisms regulating translation in eukaryotes and prokaryotes.