Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven")
Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven")
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来自臭椿（“天堂之树”）树皮的四环三萜类化合物和萜烯化香豆素
DOI：
10.1016/j.phytochem.2012.10.008
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发表时间：
2013-02-01
期刊：
影响因子：
3.8
通讯作者：
Hu, Jin-Feng
中科院分区：
文献类型：
--
作者：
Hong, Zhi-Lai;Xiong, Juan;Hu, Jin-Feng
从臭椿（Ailanthus altissima）树皮中分得四环三萜类化合物（altissimanins A-E，1-5）和一个萜基香豆素（altissimacoumarin G，6），沿着1 - 5个已知化合物（7-21）。化合物1-6的结构经波谱学方法和化学转化方法确定。阿尔提西马宁A（1）是一种侧链上带有不常见的氧杂环丁烷环的替鲁卡勒烷型三萜类化合物，而阿尔提西马宁D（4）和E（5）是两种前所未有的二聚体，每种二聚体由一个替鲁卡勒烷型三萜类化合物和一个达玛烷型三萜类化合物组成。评价所有分离株对一小组人癌细胞系的细胞毒性作用。(c)2012爱思唯尔有限公司保留所有权利。
Tetracyclic triterpenoids (named as altissimanins A-E, 1-5) and a terpenylated coumarin (denominated as altissimacoumarin G, 6), along with fifteen known compounds (7-21) were isolated from the bark of Ailanthus altissima. Structures of compounds 1-6 were established by spectroscopic methods and chemical transformations. Altissimanin A (1) is a tirucallane-type triterpenoid bearing an uncommon oxetane ring in the side-chain, while altissimanins D (4) and E (5) are two unprecedented dimers each consisting of one tirucallane-type and one dammarane-type triterpenoid moiety. All the isolates were evaluated for their cytotoxic effects against a small panel of human cancer cell lines. (c) 2012 Elsevier Ltd. All rights reserved.