Retinopathy and attenuated circadian entrainment in Crx-deficient mice
Retinopathy and attenuated circadian entrainment in Crx-deficient mice
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DOI：
10.1038/70591
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发表时间：
1999-12-01
期刊：
影响因子：
30.8
通讯作者：
Cepko, CL
中科院分区：
文献类型：
--
作者：
Furukawa, T;Morrow, EM;Cepko, CL
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland(1,2). Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific genes in the pineal gland. Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3-5), retinitis pigmentosa(5) (RP) and Leber congenital amaurosis(5,6) (LCA), which all lead to loss of vision. We generated mice carrying a targeted disruption of Crx. Crx(-/-) mice do not elaborate photoreceptor outer segments and lacked rod and cone activity as assayed by electroretinogram (ERG). Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx(-/-) mice.
