Speech entrainment compensates for Broca's area damage
Speech entrainment compensates for Broca's area damage
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DOI：
10.1016/j.cortex.2015.04.013
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发表时间：
2015-08-01
期刊：
影响因子：
3.6
通讯作者：
Rorden, Chris
中科院分区：
文献类型：
--
作者：
Fridriksson, Julius;Basilakos, Alexandra;Rorden, Chris
语音夹带(SE)，即在线模仿视听语音模型，已被证明可以提高布罗卡氏失语症患者的语音流畅性。然而，并不是所有的失语症患者都能从SE中受益。这项研究的目的是确定预测积极反应SE流利诱导效应的皮质损伤模式。本研究纳入44例慢性左半球卒中患者(女性15例)。参与者完成了两个任务：1)自发的语音产生，2)视听SE。计算每分钟不同单词的数量作为每项任务的语音输出测量，SE和自发语音条件之间的差异产生流利性改善的衡量标准。体素损害-症状图(VLSM)被用来将自发言语、SE和SE相关改善的每分钟不同词数与脑损伤的模式联系起来，以预测与SE流利诱导反应相关的损害位置。Broca失语症患者在SE过程中每分钟的不同词数比自然语言显著增加。在其他类型的失语症患者中没有看到类似的改善模式。VLSM分析显示，额叶下回的损伤可以预测这种反应。结果表明，语篇效应通过内部监控过程为言语产生提供了一个替代目标，从而发挥了流利诱导的作用。在临床上，这些结果进一步支持使用SE来改善语音产生，并可能有助于选择SE患者进行治疗。(C)2015爱思唯尔有限公司。保留所有权利。
Speech entrainment (SE), the online mimicking of an audiovisual speech model, has been shown to increase speech fluency in patients with Broca's aphasia. However, not all individuals with aphasia benefit from SE. The purpose of this study was to identify patterns of cortical damage that predict a positive response SE's fluency-inducing effects. Forty-four chronic patients with left hemisphere stroke (15 female) were included in this study. Participants completed two tasks: 1) spontaneous speech production, and 2) audiovisual SE. Number of different words per minute was calculated as a speech output measure for each task, with the difference between SE and spontaneous speech conditions yielding a measure of fluency improvement. Voxel-wise lesion-symptom mapping (VLSM) was used to relate the number of different words per minute for spontaneous speech, SE, and SE-related improvement to patterns of brain damage in order to predict lesion locations associated with the fluency-inducing response to SE. Individuals with Broca's aphasia demonstrated a significant increase in different words per minute during SE versus spontaneous speech. A similar pattern of improvement was not seen in patients with other types of aphasia. VLSM analysis revealed damage to the inferior frontal gyrus predicted this response. Results suggest that SE exerts its fluency-inducing effects by providing a surrogate target for speech production via internal monitoring processes. Clinically, these results add further support for the use of SE to improve speech production and may help select patients for SE treatment. (C) 2015 Elsevier Ltd. All rights reserved.