ASSEMBLY UNITS OF CLATHRIN COATS
ASSEMBLY UNITS OF CLATHRIN COATS
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DOI：
10.1038/289420a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
BRANTON, D
中科院分区：
文献类型：
--
作者：
UNGEWICKELL, E;BRANTON, D
网格蛋白是一种分子量为180，000的多肽，是形成被膜小凹和囊泡外壳的多边形网络的主要成分;这些囊泡在膜细胞器之间的细胞内运输中发挥作用。纯化的[小牛脑]网格蛋白外套可逆地解离成三层，三层是由3个通常弯曲的、从中心辐射的柔性腿组成的结构。测定了这些三骨架的MW，它们含有网格蛋白的三聚体以及约3条轻MW多肽链。
Clathrin, a polypeptide of MW 180,000, is the main constituent of the polygonal network that forms the coat of coated pits and vesicles; these vesicles play a part in intracellular transport between membranous organelles. Purified [calf brain] clathrin coats dissociate reversibly into triskelions, structures composed of 3 usually bent, flexible legs radiating from a center. The MW of these triskelions was determined and they contain trimers of clathrin together with about 3 light MW polypeptide chains.