Effects of hypoxia on the circadian patterns in men
Effects of hypoxia on the circadian patterns in men
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DOI：
10.1089/152702903769192269
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发表时间：
2003-09-01
影响因子：
2.1
通讯作者：
Mortola, JP
中科院分区：
文献类型：
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作者：
Bosco, G;Ionadi, A;Mortola, JP
我们检验了急性缺氧可能改变成年人体温昼夜节律模式的假设。6名健康受试者在常氧、低氧（类似于吸入13%的O-2）和再次常氧下进行研究，每次持续>24小时，间隔几天，持续觉醒和最小活动的恒定常规方案。一些参数（例如，鼓膜和腹部温度，心率）连续记录;其它（例如，氧消耗和肺通气）每2小时监测类似的10分钟。鼓室，腹部和小腿皮肤温度的昼夜节律振荡的幅度在缺氧中降低，平均，分别为61%，80%和50%的常氧振幅。氧耗和肺通气，这提出了一个昼夜模式，在常氧缺氧期间不再有显着的振荡，而相反的情况下，心率和舒张压。因此，急性缺氧可以扰乱正常的昼夜节律模式，特别是降低体温。这些影响在性质上与在慢性缺氧动物和人类中观察到的类似，可能导致高海拔地区的睡眠障碍。
We tested the hypothesis that acute hypoxia may alter the circadian pattern of body temperature in adult humans. Six healthy subjects were studied in normoxia, hypoxia (similar to13% inspired O-2), and again normoxia, each session lasting >24 h and spaced a few days apart, with a constant routine protocol of sustained wakefulness and minimal activity. Some parameters (e.g., tympanic and abdominal temperatures, heart rate) were recorded continuously; others (e.g., oxygen consumption and pulmonary ventilation) were monitored for similar to10 min every 2 h. The amplitudes of the circadian oscillation of tympanic, abdominal, and calf skin temperatures were reduced in hypoxia, averaging, respectively, 61%, 80% and 50% of the normoxic amplitude. Oxygen consumption and pulmonary ventilation, which presented a circadian pattern in normoxia had no longer significant oscillations during hypoxia, whereas the opposite was the case for heart rate and diastolic pressure. Therefore, acute hypoxia can disturb the normal circadian patterns and, specifically, depress those of body temperature. These effects, qualitatively similar to those observed in chronically hypoxic animals and humans, could contribute to sleep disturbances at high altitude.