Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage
Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage
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DOI：
10.1111/aji.12546
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发表时间：
2016-09-01
影响因子：
3.6
通讯作者：
Yamada, Hideto
中科院分区：
文献类型：
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作者：
Ebina, Yasuhiko;Shimada, Shigeki;Yamada, Hideto
本前瞻性研究的目的是评价遗漏流产胎儿染色体核型正常(MN)和遗漏流产胎儿染色体异常(MA)蜕膜组织中辅助性T细胞(Th)、细胞毒性T细胞(TC)和调节性T细胞(Treg)的表型差异。取15例人工流产(IA)患者的蜕膜和19例非妊娠妇女(EM)的子宫内膜。结果MN患者外周血中的干扰素(+)、CD25(高)Foxp3(+)、CD25(高)Foxp3(+)细胞的百分率明显高于MA和IA组。结论蜕膜中干扰素-(+)T细胞和Treg细胞的活化可能与MN的病理生理机制有关。
ProblemThe aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus (MN) and missed miscarriage with an abnormal chromosome karyotype of a fetus (MA).Methods of studyThe decidua of 19 MN and 28 MA was obtained. Additionally, the decidua of 15 induced abortion (IA) and the endometrium of 19 non-pregnant women (EM) were obtained. IFN-(+), IL-17(+), CD25(high)Foxp3(+) cells in CD4(+) (Th) cells, and IFN-(+) cells in CD8(+) (Tc) cells were evaluated by flow cytometry.ResultsThe percentages of IFN-(+) Tc and CD4(+)CD25(high)Foxp3(+) (Treg) cells in MN were significantly increased as compared with MA and IA. The percentage of IFN-(+) Th in MN was increased as compared with IA.ConclusionActivation of IFN-(+) Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN.