The beneficial effects of Gracilaria lemaneiformis polysaccharides on obesity and the gut microbiota in high fat diet-fed mice
The beneficial effects of Gracilaria lemaneiformis polysaccharides on obesity and the gut microbiota in high fat diet-fed mice
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龙须菜多糖对高脂饮食喂养小鼠的肥胖和肠道微生物群的有益影响
DOI：
10.1016/j.jff.2018.04.041
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发表时间：
2018-07-01
影响因子：
5.6
通讯作者：
Ai, Chunqing
中科院分区：
文献类型：
--
作者：
Sun, Xiaona;Duan, Mengmeng;Ai, Chunqing
龙须菜多糖（Gracilaria lemaneiformis，GLPs）具有多种生物活性，但其对饮食诱导肥胖的影响及其机制尚不清楚。这项研究表明，在高脂肪饮食（HFD）喂养的小鼠中，饮食补充GLP可减少体重增加并改善身体组成，而不会减少摄食量。脂多糖能减少肝脏和脂肪组织中的脂肪堆积，修复高脂膳食对肠道的损伤。这些影响可能与肠道微生物群的调节有关，导致与正常微生物群相似的特定微生物群。肠道微生物群的变化可能通过短链脂肪酸依赖性途径影响脂质相关基因的表达。结果表明，GLPs可以通过改善肠道菌群失调来减轻HFD诱导的肥胖，提示G。可开发为改善代谢综合征和肠道疾病的食品补充剂。
Some polysaccharides from Gracilaria lemaneiformis (GLPs) are shown to have various activities, but the effects of GLPs on diet-induced obesity and the underlying mechanisms are unclear. This study indicated that dietary supplementation with GLPs reduced weight gain and improved body composition in high fat diet (HFD)-fed mice without reduced food consumption. Fat accumulation in the liver and adipose tissues was reduced by GLPs, and the damages of HFD on the intestine were repaired. These effects could be associated with the modulation of the gut microbiota, resulting in a specific microbiota that similar to normal microbiota. Changes in the gut microbiota may affect the expression of lipid-related genes via short chain fatty acids-dependent pathways. It revealed that GLPs can alleviate HFD-induced obesity by improving the gut microbiota dysbiosis, suggesting that G. lemaneiformis can be developed as food supplement to improve metabolic syndrome and intestinal diseases.