Receptor Tyrosine Kinase Signaling and Primordial Germ Cell Development-猫眼课题宝

受体酪氨酸激酶信号传导和原始生殖细胞发育

DOI：

发表时间：

2004

期刊：

Cell Cycle

影响因子：

4.3

通讯作者：

中科院分区：

生物学3区

文献类型：

作者：

Willis X. Li

Primordial germ cells (PGCs) give rise to sperms and eggs. Their development is crucial to species propagation and has to be precisely controlled. Studies in several model organisms have identified many genes involved in the specification and guided migration of PGCs. However, the mechanisms governing the behaviors of this unique type of cells remain to be investigated. Interestingly, PGCs share certain cellular properties with metastasizing cancer cells including proliferation, invasion of other tissues, survival, and migration. Recently we have shown that in Drosophila the receptor tyrosine kinase Torso activates both STAT and Ras during the early phase of PGC development. In later stages, activation of both STAT and Ras, likely by other molecules, is required continuously for PGC migration. The requirement for RTK suggests molecular conservation between flies and mice in PGC development and also suggests that germ cells and cancer cells share certain intracellular signaling strategies.