Endoscopic and pathologic changes of the upper gastrointestinal tract in Crohn's disease.
Endoscopic and pathologic changes of the upper gastrointestinal tract in Crohn's disease.
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DOI：
10.1155/2014/610767
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发表时间：
2014
影响因子：
--
通讯作者：
Hibi T
中科院分区：
文献类型：
--
作者：
Sakuraba A;Iwao Y;Matsuoka K;Naganuma M;Ogata H;Kanai T;Hibi T
背景。克罗恩病 (CD) 可能累及胃肠道的任何部分。我们评估了 CD 中上消化道 (UGI) 病变的患病率和特征。方法。这是一项回顾性研究，纳入了 138 名接受食管胃十二指肠镜检查 (EGD) 的 CD 患者。评估食管、胃和十二指肠中克罗恩病特异性内镜病变的发生率，并进行免疫组织化学分析。对接受两次或两次以上 EGD 的患者评估 UGI 病变的变化。结果。在 138 名患者中，51.3% 患有克罗恩病特异性 UGI 病变。食管、胃上中段、胃下段、十二指肠球部和十二指肠第二部分的克罗恩病特异性病变发生率分别为6.5%、47.8%、24.6%、31.9%和18.1%。上中胃、下胃和十二指肠球部检出肉芽肿的比例分别为 6.1%、25.0% 和 11.4%，但食管和十二指肠第二部分没有肉芽肿。对 37 例进行了幽门螺杆菌分析，其中 4 例呈阳性（10.8%）。 49 例中，14 例 (28.5%) 的 UGI 病变有所改善，59.2% 的患者无变化，12.2% 的患者恶化。结论。在我们的病例系列中，克罗恩病特定 UGI 病变的患病率很常见，免疫组织化学研究表明大多数与幽门螺杆菌感染无关。整个病程中上消化道病变恶化的情况很少见。
Background. Crohn's disease (CD) may involve any part of the gastrointestinal tract. We assessed the prevalence and features of upper gastrointestinal (UGI) lesions in CD. Methods. This was a retrospective study that included 138 CD patients that underwent esophagogastroduodenoscopy (EGD). The rate of Crohn's specific endoscopic lesions in the esophagus, stomach, and duodenum was assessed, and immunohistochemical analysis was performed. Changes in the UGI lesions were assessed in those who had two or more EGD. Results. Of 138 patients, 51.3% had Crohn's specific UGI lesions. The rates of Crohn's specific lesion in the esophagus, upper-to-middle stomach, lower stomach, duodenal bulb, and 2nd portion of the duodenum were 6.5%, 47.8%, 24.6%, 31.9%, and 18.1%, respectively. Granulomas were detected in 6.1%, 25.0%, and 11.4% in the upper-to-middle stomach, lower stomach, and duodenal bulb, respectively, but none in the esophagus and 2nd portion of the duodenum. Thirty-seven were analyzed for Helicobacter pylori and 4 were positive (10.8%). Improvements of UGI lesions were seen in 14 out of 49 (28.5%) and were unchanged in 59.2% and worsened in 12.2%. Conclusions. The prevalence of Crohn's specific UGI lesions was common in our case series, and immunohistochemical studies suggested that the majority was unrelated to Helicobacter pylori infection. Worsening of UGI lesions over the course was rare.
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影响因子：
1.9
作者：
Witte, AMC;Veenendaal, RA;Lamers, CBHW
通讯作者：
Lamers, CBHW
影响因子：
4.9
作者：
Chow, Dorothy K. L.;Sung, Joseph J. Y.;Chan, Francis K. L.
通讯作者：
Chan, Francis K. L.
影响因子：
3.2
作者：
Mottet, Christian;Juillerat, Pascal;Froehlich, Florian
通讯作者：
Froehlich, Florian
DOI：
10.1007/s004280050133
发表时间：
1998-01-01
期刊：
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
影响因子：
--
作者：
Oberhuber, G;Hirsch, M;Stolte, M
通讯作者：
Stolte, M
影响因子：
3.1
作者：
Annunziata, Maria Laura;Caviglia, Renato;Cicala, Michele
通讯作者：
Cicala, Michele