A model of motor and sensory axon activation in the median nerve using surface electrical stimulation
A model of motor and sensory axon activation in the median nerve using surface electrical stimulation
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DOI：
10.1007/s10827-018-0689-5
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发表时间：
2018-08-01
影响因子：
1.2
通讯作者：
Polasek, Katharine H.
中科院分区：
文献类型：
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作者：
Gaines, Jessica L.;Finn, Kathleen E.;Polasek, Katharine H.
表面电刺激有可能成为治疗各种医疗状况的一种强大且非侵入性的治疗方法，但目前很难获得一致的诱发反应。一个可行的临床系统必须能够适应个体的差异，以产生可重复的结果。为了更全面地研究这些变化的影响，而不需要对人类受试者进行详尽的测试，创建了一个计算机模型系统来预测由于肘部表面电刺激而导致的正中神经的运动和感觉轴突激活。建立了基于解剖学的手臂有限元模型，以准确预测表面电刺激产生的电压。此外，基于先前发表的模型开发了两个轴突模型，以纳入感觉轴突和运动轴突之间的生理差异。这产生了可以重现传导速度、强度持续时间曲线和激活阈值的实验结果的轴突模型。模型中反映了实验获得的运动轴突和感觉轴突之间动作电位形状的差异。这些模型预测感觉轴突的阈值低于相同直径的运动轴突，从而允许一系列感觉轴突在任何运动轴突之前被激活。该模型系统将成为开发表面电刺激作为针对特定神经功能的方法的有用工具。
Surface electrical stimulation has the potential to be a powerful and non-invasive treatment for a variety of medical conditions but currently it is difficult to obtain consistent evoked responses. A viable clinical system must be able to adapt to variations in individuals to produce repeatable results. To more fully study the effect of these variations without performing exhaustive testing on human subjects, a system of computer models was created to predict motor and sensory axon activation in the median nerve due to surface electrical stimulation at the elbow. An anatomically-based finite element model of the arm was built to accurately predict voltages resulting from surface electrical stimulation. In addition, two axon models were developed based on previously published models to incorporate physiological differences between sensory and motor axons. This resulted in axon models that could reproduce experimental results for conduction velocity, strength-duration curves and activation threshold. Differences in experimentally obtained action potential shape between the motor and sensory axons were reflected in the models. The models predicted a lower threshold for sensory axons than motor axons of the same diameter, allowing a range of sensory axons to be activated before any motor axons. This system of models will be a useful tool for development of surface electrical stimulation as a method to target specific neural functions.