Circulating glucagon is associated with inflammatory mediators in metabolically compromised subjects
Circulating glucagon is associated with inflammatory mediators in metabolically compromised subjects
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DOI：
10.1530/eje-11-0384
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发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Fernandez-Real, Jose M.
中科院分区：
文献类型：
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作者：
Ortega, Francisco J.;Moreno-Navarrete, Jose M.;Fernandez-Real, Jose M.
背景：急性期介质通过改变循环激素促进代谢变化。然而，在肥胖相关的慢性低度炎症中，胰高血糖素与炎症参数之间的联系几乎没有数据。研究设计：我们进行了横断面和纵向（饮食引起的体重减轻）研究。方法：对316例（男性250例，女性66例）患者循环胰高血糖素浓度（ELISA）、糖脂代谢指标、白细胞介素6 （IL6）、补体因子B （CFB）进行分析。减肥的效果在一个独立的20名受试者队列中进行了调查。结果：循环胰高血糖素与血糖呈显著相关(r=0.407， P
Background: Acute phase mediators promote metabolic changes by modifying circulating hormones. However, there is virtually no data about the link between glucagon and inflammatory parameters in obesity-related chronic low-grade inflammation.Study design: We performed both cross-sectional and longitudinal (diet-induced weight loss) studies.Methods: Circulating glucagon concentrations (ELISA), parameters of glucose and lipid metabolism, interleukin 6 (IL6), and complement factor B (CFB) were analyzed in 316 subjects (250 men and 66 women). The effects of weight loss were investigated in an independent cohort of 20 subjects.Results: Circulating glucagon significantly correlated with glucose (r=0.407, P