Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant.
Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant.
复制标题
鉴定出三种高度减毒的鼠伤寒沙门氏菌突变体，它们比典型的 aroA 突变体在小鼠中更具免疫原性和保护性。
DOI：
10.1128/iai.66.7.3378-3383.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Heffron,F
中科院分区：
文献类型：
--
作者：
Valentine,PJ;Devore,BP;Heffron,F
A panel ofSalmonella typhimurium14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as liveSalmonellaoral-vaccine candidates. A prototypicalaroAmutant was chosen as a basis of comparison. From the panel of mutants initially chosen for this study, three mutants with comparable levels of attenuation elicited higherSalmonella-specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than thearoAvaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than thearoAcontrol strain, after a single oral dose of 1 × 109to 2 × 109bacteria.
