Cancer mortality in a cohort of asbestos textile workers
Cancer mortality in a cohort of asbestos textile workers
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DOI：
10.1038/sj.bjc.6602240
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发表时间：
2005-02-14
影响因子：
8.8
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Pira, E;Pelucchi, C;La Vecchia, C
一组889名男性和1077名女性在1946年至1984年期间受雇于一家前意大利领先的石棉（主要是纺织品）公司至少1个月，其特征是经常在短时间内极度严重暴露，随访至1996年，共观察53024人年。就业数据是从工厂人员记录中获得的，而生命状况和死亡原因则是通过市政登记册和地方卫生单位确定的。我们观察到222例癌症死亡，而预期为116.4例（标准化死亡率比，SMR = 191）。比率最高的是胸膜癌（SMR = 4105）、腹膜癌（SMR = 1817）和肺癌（SMR = 282）。我们观察到肺癌和腹膜癌与就业时间的直接关系，以及肺癌和间皮瘤与首次就业时间的直接关系。胸膜癌风险与工龄无关（SMR = 3428为就业< 1年，7659为1 - 4年，2979为5 - 9年和2130为>= 10年）。肺癌的相应SMR分别为139、251、233和531。卵巢癌（SMR = 261）、喉癌（SMR = 238）和口咽癌（SMR = 226）的比率无显著增加。本研究证实并进一步量化了胸膜间皮瘤潜伏期和肺癌累积暴露的中心作用。
A cohort of 889 men and 1077 women employed for at least 1 month between 1946 and 1984 by a former Italian leading asbestos ( mainly textile) company, characterised by extremely heavy exposures often for short durations, was followed up to 1996, for a total of 53 024 person- years of observation. Employment data were obtained from factory personnel records, while vital status and causes of death were ascertained through municipality registers and local health units. We observed 222 cancer deaths compared with 116.4 expected ( standardized mortality ratio, SMR = 191). The highest ratios were found for pleural ( SMR = 4105), peritoneal ( SMR = 1817) and lung ( SMR = 282) cancers. We observed direct relationships with duration of employment for lung and peritoneal cancer, and with time since first employment for lung cancer and mesothelioma. Pleural cancer risk was independent from duration ( SMR = 3428 for employment < 1 year, 7659 for 1 - 4 years, 2979 for 5 - 9 years and 2130 for >= 10 years). Corresponding SMRs for lung cancer were 139, 251, 233 and 531. Nonsignificantly increased ratios were found for ovarian ( SMR = 261), laryngeal ( SMR = 238) and oro- pharyngeal ( SMR = 226) cancers. This study confirms and further quantifies the central role of latency in pleural mesothelioma and of cumulative exposure in lung cancer.