Biofilms as a mechanism of bacterial resistance.
Biofilms as a mechanism of bacterial resistance.
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DOI：
10.1016/j.ddtec.2014.02.003
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发表时间：
2014-03-01
期刊：
影响因子：
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通讯作者：
Bonnaure-Mallet, Martine
中科院分区：
文献类型：
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作者：
Jolivet-Gougeon, Anne;Bonnaure-Mallet, Martine
在生物膜内，抗菌剂必须克服高细胞密度、耐药突变体数量增加、物质传递、分子交换，如高水平的β-内酰胺酶或外排泵表达诱导剂，以及特定的适应细胞，即所谓的持续体。生物膜内的环境调节对抗生素的反应，特别是当涉及SOS反应或DNA修复系统时。暴露于亚抑制浓度的抗生素可促进生物被膜的形成和诱变。因此，对细胞应激的全球反应似乎是抗生素诱导的生物膜形成的原因。
Inside the biofilm, antimicrobial agents must overcome high cell density, an increased number of resistant mutants, substance delivery, molecular exchanges, such as high levels of beta-lactamases or inducers of efflux pump expression, and specific adaptive cells, so-called persisters. The environment within the biofilm modulates the response to antibiotics, especially when the SOS response or DNA repair systems are involved. Exposure to subinhibitory concentrations of antibiotics can enhance biofilm formation and mutagenesis. Thus, a global response to cell stress seems to be responsible for antibiotic-induced biofilm formation.