Translation initiation in cancer: a novel target for therapy.
Translation initiation in cancer: a novel target for therapy.
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DOI：
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发表时间：
2002-09
影响因子：
5.7
通讯作者：
F. Meric;K. Hunt
中科院分区：
文献类型：
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作者：
F. Meric;K. Hunt
翻译起始响应于营养物质的可用性和促有丝分裂刺激而被调节，并且与细胞周期进展和细胞生长偶联。在癌症中发生翻译控制的几种改变。变异的mRNA序列可以改变单个mRNA分子的翻译效率，这反过来又在癌症生物学中发挥作用。翻译机制组分的表达或可用性的变化以及通过信号转导途径激活翻译的变化可导致更多的全局变化，例如参与细胞生长和增殖的mRNA分子的蛋白质合成和翻译激活的总体速率的增加。我们回顾了翻译控制的基本原理，在癌症中遇到的改变，以及针对翻译起始的选定疗法，以帮助阐明新的治疗途径。
Translation initiation is regulated in response to nutrient availability and mitogenic stimulation and is coupled with cell cycle progression and cell growth. Several alterations in translational control occur in cancer. Variant mRNA sequences can alter the translational efficiency of individual mRNA molecules, which in turn play a role in cancer biology. Changes in the expression or availability of components of the translational machinery and in the activation of translation through signal transduction pathways can lead to more global changes, such as an increase in the overall rate of protein synthesis and translational activation of the mRNA molecules involved in cell growth and proliferation. We review the basic principles of translational control, the alterations encountered in cancer, and selected therapies targeting translation initiation to help elucidate new therapeutic avenues.