EEG microstates suggest atypical resting-state network activity in high-functioning children and adolescents with autism spectrum development.
EEG microstates suggest atypical resting-state network activity in high-functioning children and adolescents with autism spectrum development.
复制标题
脑电图微观状态表明患有自闭症谱系发展的高功能儿童和青少年存在非典型的静息态网络活动。
DOI：
10.1111/desc.13231
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发表时间：
2022
影响因子：
3.7
通讯作者：
Townsend,Jeanne
中科院分区：
文献类型：
--
作者：
Takarae,Yukari;Zanesco,Anthony;Keehn,Brandon;Chukoskie,Leanne;Müller,Ralph-Axel;Townsend,Jeanne
EEG微观状态代表反映大规模网络同步活动的瞬态皮层电事件，这允许以亚秒级分辨率研究大脑动力学。我们记录了38名患有自闭症谱系发育（ASD）的儿童和青少年以及48名年龄，智商，性别和惯用手匹配的典型发育（TD）参与者的静息EEG。使用头皮电压地形图的改进的k均值聚类将EEG分割成微观状态的时间序列。ASD组中特定微状态（C型）的频率和全局解释方差（GEV）显著低于TD组，而相同微状态的持续时间与ASD相关行为的存在相关。在TD组中，这种微状态的持续时间也与参与者的年龄呈正相关，但在ASD组中则不然。此外，微状态的频率和持续时间仅在TD组中与总体α功率显著相关。ASD组中另一个微状态（G型）的信号强度和GEV大于TD组，并且相关的地形图模式在ASD组中差异更大。虽然需要更多的工作来澄清潜在的神经源，但现有的文献支持两个微观状态与默认模式和显着性网络之间的关联。目前的研究表明，休息皮层网络活动的时间动力学的具体改变，以及它们的发展轨迹和关系的α功率，这已被提出来反映减少神经抑制ASD。
EEG microstates represent transient electrocortical events that reflect synchronized activities of large‐scale networks, which allows investigations of brain dynamics with sub‐second resolution. We recorded resting EEG from 38 children and adolescents with Autism Spectrum Development (ASD) and 48 age, IQ, sex, and handedness‐matched typically developing (TD) participants. The EEG was segmented into a time series of microstates using modified k‐means clustering of scalp voltage topographies. The frequency and global explained variance (GEV) of a specific microstate (type C) were significantly lower in the ASD group compared to the TD group while the duration of the same microstate was correlated with the presence of ASD‐related behaviors. The duration of this microstate was also positively correlated with participant age in the TD group, but not in the ASD group. Further, the frequency and duration of the microstate were significantly correlated with the overall alpha power only in the TD group. The signal strength and GEV for another microstate (type G) was greater in the ASD group than the TD group, and the associated topographical pattern differed between groups with greater variations in the ASD group. While more work is needed to clarify the underlying neural sources, the existing literature supports associations between the two microstates and the default mode and salience networks. The current study suggests specific alterations of temporal dynamics of the resting cortical network activities as well as their developmental trajectories and relationships to alpha power, which has been proposed to reflect reduced neural inhibition in ASD.