Effect of running intensity on intestinal permeability
Effect of running intensity on intestinal permeability
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DOI：
10.1152/jappl.1997.82.2.571
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发表时间：
1997-02-01
影响因子：
3.3
通讯作者：
Gisolfi, CV
中科院分区：
文献类型：
--
作者：
Pals, KL;Chang, RT;Gisolfi, CV
肠道通透性增强与长跑运动员的胃肠道疾病有关。本研究的主要目的是通过乳果糖和鼠李糖尿微量排泄试验来评价运动强度对小肠通透性的影响。次要目的是评估小肠通透性与胃肠道症状的关系，并以蔗糖为探针评估胃损伤。6名健康志愿者，男5人，女1人，年龄30±2岁，最大摄氧量(Vo(2峰))=57.7±2.1ml。Kg(-1)。Min(-1)]休息或在40、60或80%Vo(2峰值)下在中等环境(22℃，50%相对湿度)下进行60min的跑步机运动。静息或运动30min后，摄取通透性测试液(蔗糖5g、乳果糖5g、鼠李糖2g/50ml水，相当于800moM)。用乳果糖/鼠李糖比值的尿液排泄率(6h)评价小肠通透性，并用高效液相色谱法测定各探针的浓度。与安静、40和60%Vo(2峰)相比，80%Vo(2峰)下运行的小鼠小肠通透性增加(P<；0.05)，平均值分别为摄入量0.107+/-0.021(SE)、0.048+/-0.009、0.056+/-0.005和0.064+/-0.010%。小肠通透性的增加不会导致胃肠道症状的发生率更高，尿糖的恢复也没有反映胃通透性的增加。大强度跑后小肠通透性增加的意义和机制值得进一步研究。
Enhanced intestinal permeability has been associated with gastrointestinal disorders in long-distance runners. The primary purpose of this study was to evaluate the effect of running intensity on small intestinal permeability by using the lactulose and rhamnose differential urinary excretion test. Secondary purposes included assessing the relationship between small intestinal permeability and gastrointestinal symptoms and evaluating gastric damage by using sucrose as a probe. Six healthy volunteers [5 men, 1 woman; age = 30 +/- 2 yr; peak O-2 uptake (Vo(2peak)) = 57.7 +/- 2.1 ml . kg(-1). min(-1)] rested or performed treadmill exercise at 40, 60, or 80% Vo(2peak) for 60 min in a moderate environment (22 degrees C, 50% relative humidity). At 30 min into rest or exercise, the permeability test solution (5 g sucrose, 5 g lactulose, 2 g rhamnose in 50 ml water; similar to 800 mosM) was ingested. Urinary excretion rates (6 h) of the lactulose-to-rhamnose ratio were used to assess small intestinal permeability, and concentrations of each probe were determined by using high-performance liquid chromatography. Running at 80% Vo(2peak) increased (P < 0.05) small intestinal permeability compared with rest, 40, and 60% Vo(2peak) with mean values expressed as percent recovery of ingested dose of 0.107 +/- 0.021(SE), 0.048 +/- 0.009, 0.056 +/- 0.005, and 0.064 +/- 0.010%, respectively. Increases in small intestinal permeability did not result in a higher prevalence of gastrointestinal symptoms, and urinary recovery of sucrose did not reflect increased gastric permeability. The significance and mechanisms involved in increased small intestinal permeability after high-intensity running merit further investigation.