Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
复制标题
牛磺酸和烟酸为预防仓鼠化学诱导的肺纤维化提供了一种新的治疗方式。
DOI：
10.1007/978-1-4615-3436-5_39
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发表时间：
1992
影响因子：
--
通讯作者：
Wang,Q
中科院分区：
文献类型：
--
作者：
Giri,SN;Wang,Q
牛磺酸是一种含硫的β-氨基酸，在大多数哺乳动物组织中以高浓度存在。尽管牛磺酸不是哺乳动物蛋白质的组成部分，但它在心血管和神经系统1,2的病理生理学以及胆汁酸3的结合中发挥着重要作用。牛磺酸对氧化剂引起的组织损伤的有益作用归因于其稳定生物膜 4,5 和清除包括次氯酸在内的活性氧 (ROS) 的能力 6-8。牛磺酸对心血管和中枢神经系统的多种影响可能与钙的重新分配有关，因为牛磺酸会改变钙的转运9,10。已经证明，外源性施用牛磺酸可以提供针对氧化剂引起的肺损伤的保护11,12此外，Nakashima等人1.13报告了牛磺酸对实验引起的肝损伤的治疗和预防作用。
Taurine, a sulfur containing ß-amino acid, is present in high concentrations in most mammalian tissues. Although taurine is not a constituent of mammalian proteins, it plays an important role in the pathophysiology of cardiovascular and nervous systems1,2and conjugation of bile acids3. The beneficial effects of taurine against oxidant-induced tissue injury have been attributed to its ability to stabilize biomembranes4,5and scavenge reactive oxygen species (ROS) including hypochlorous acid6–8. Several effects of taurine on the cardiovascular and central nervous systems may be related to calcium redistribution since taurine alters calcium transport9,10. It has been demonstrated that exogenously administered taurine would offer protection against oxidant-induced lung damage11,12In addition, Nakashima et a1.13reported therapeutic and prophylactic effects of taurine on experimentally-induced liver injury.