Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study
Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study
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DOI：
10.1016/j.envres.2018.10.007
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发表时间：
2019-01-01
影响因子：
8.3
通讯作者：
Terada，Yukihiro
中科院分区：
文献类型：
--
作者：
Maeda，Eh;Murata，Katsuyuki;Terada，Yukihiro
背景甲基汞暴露是日常鱼类摄入造成的常见健康风险。然而，关于甲基汞与不孕症之间联系的研究有限且不一致。此外，之前的流行病学研究还没有解释甲基汞和硒之间的相互作用。我们的目的是探讨环境金属暴露与女性生育力之间的关系。方法本病例对照研究包括98名接受生育治疗的不孕妇女（不孕组）和43名30多岁的女工（对照组），提供血液样本并返回生活方式和饮食特征调查问卷。比较各组之间的汞、铅、镉、砷、锰、锌和硒的血液水平。抗苗勒氏管激素与金属元素之间进行Spearman相关分析。结果不孕组的平均血硒水平(±SD)和硒/汞摩尔比(分别为189±25μg/L和94.6±44.3)显着低于对照组(200±25μg/L和118.4±70.5)。相比之下，调整血硒和年龄后，不孕组的血汞水平显着高于对照组。调整其他金属和潜在混杂因素后的多重逻辑回归分析证实，不孕症与汞含量升高和硒含量降低之间存在显着关联。抗苗勒氏管激素和金属之间没有观察到显着相关性。结论甲基汞和硒暴露似乎分别对女性生育能力产生不利影响和保护作用。这是第一份表明甲基汞和硒之间与人类女性生育能力之间的拮抗相互作用的报告。
BackgroundMethylmercury exposure is a common health risk resulting from daily fish intake. However, studies addressing the link between methylmercury and infertility are limited and also inconsistent. In addition, no previous epidemiological studies have accounted for the interaction between methylmercury and selenium. We aimed to investigate the association between environmental exposures to metals and female fertility.MethodsThis case-control study included 98 infertile women receiving fertility treatment (infertile group) and 43 female workers in their thirties (control group) who provided blood samples and returned a questionnaire on lifestyles and dietary characteristics. Blood levels of mercury, lead, cadmium, arsenic, manganese, zinc, and selenium were compared between the groups. Spearman correlation analyses between anti-Müllerian hormone and the metals were conducted.ResultsThe mean selenium level in blood (± SD) and the selenium/mercury molar ratio were significantly lower in the infertile group (189 ± 25 μg/L and 94.6 ± 44.3, respectively) than in the control group (200 ± 25 μg/L and 118.4 ± 70.5). By contrast, blood mercury levels after adjusting for blood selenium and age were significantly higher in the infertile group than in the control group. Multiple logistic regression analyses with the adjustment for the other metals and potential confounders confirmed significant associations of infertility with elevated mercury and reduced selenium levels. No significant correlations were observed between anti-Müllerian hormone and metals.ConclusionsMethylmercury and selenium exposures appear to have adverse and protective effects on female fertility, respectively. This is the first report to suggest the antagonistic interaction between methylmercury and selenium in relation to human female fertility.