Enzyme Discovery and Engineering for Sustainable Plastic Recycling.
Enzyme Discovery and Engineering for Sustainable Plastic Recycling.
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DOI：
10.1016/j.tibtech.2021.02.008
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发表时间：
2021-03
影响因子：
17.3
通讯作者：
Baotong Zhu;Dong Wang;Na Wei
中科院分区：
文献类型：
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作者：
Baotong Zhu;Dong Wang;Na Wei
塑料废物的急剧增加正在造成环境危机，这需要回收消费后塑料的创新技术，以实现废物的价值，同时满足环境质量目标。由酶介导的生物催化解聚已成为塑料处理和回收的有效和可持续的替代方案。已经从微生物来源发现了多种塑料降解酶。与此同时，蛋白质工程已被用来改造和优化塑料降解酶。本文重点介绍了近年来利用组学技术挖掘新型塑料降解酶以及利用蛋白质工程技术提高塑料降解酶的催化效率和稳定性的研究进展。展望了未来的研究前景和面临的挑战。
The drastically increasing amount of plastic waste is causing an environmental crisis that requires innovative technologies for recycling post-consumer plastics to achieve waste valorization while meeting environmental quality goals. Biocatalytic depolymerization mediated by enzymes has emerged as an efficient and sustainable alternative for plastic treatment and recycling. A variety of plastic-degrading enzymes have been discovered from microbial sources. Meanwhile, protein engineering has been exploited to modify and optimize plastic-degrading enzymes. This review highlights the recent trends and up-to-date advances in mining novel plastic-degrading enzymes through state-of-the-art omics-based techniques and improving the enzyme catalytic efficiency and stability via various protein engineering strategies. Future research prospects and challenges are also discussed.