Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations
Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations
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DOI：
10.1016/j.cub.2007.06.066
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发表时间：
2007-08-07
期刊：
影响因子：
9.2
通讯作者：
Malach, Rafael
中科院分区：
文献类型：
--
作者：
Nir, Yuval;Fisch, Lior;Malach, Rafael
背景资料：单个神经元的活动在多大程度上与局部场电位（LFP）和血氧水平依赖性（BOLD）功能性磁共振成像（fMRI）耦合？这个问题对于理解大脑功能以及将动物研究与fMRI联系起来具有重要意义，但仍存在争议。结果：在这里，我们报告了通过使用人类听觉皮质中的多个电极同时记录孤立单位活动和LFP的数据。我们发现了广泛的耦合水平之间的活动，个别神经元和γ LFP。然而，这种大的变异性可以主要解释（r = 0.66）的程度相邻神经元之间的放电率的相关性。重要的是，这种现象发生在感觉刺激和自发活动期间。关于耦合的神经元活动BOLD功能磁共振成像，我们发现，γ LFP耦合到BOLD测量在不同的个体（r = 0.62）。相比之下，单个单位与BOLD的耦合是高度可变的，并且再次与神经元间放电率相关性密切相关（r = 0.70）。我们的研究结果为关于神经元，LFP和BOLD信号之间耦合的核心争议提供了解决方案，首次证明，单个单元与其他测量的耦合是可变的，但它与人类听觉皮层中神经元间相关性的程度密切相关。
Background: To what extent is activity of individual neurons coupled to the local field potential (LFP) and to blood-oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI)? This issue is of high significance for understanding brain function and for relating animal studies to fMRI, yet it is still under debate.Results: Here we report data from simultaneous recordings of isolated unit activity and LFP by using multiple electrodes in the human auditory cortex. We found a wide range of coupling levels between the activity of individual neurons and gamma LFP. However, this large variability could be predominantly explained (r = 0.66) by the degree of firing-rate correlations between neighboring neurons. Importantly, this phenomenon occurred during both sensory stimulation and spontaneous activity. Concerning the coupling of neuronal activity to BOLD fMRI, we found that gamma LFP was well coupled to BOLD measured across different individuals (r = 0.62). By contrast, the coupling of single units to BOLD was highly variable and, again, tightly related to interneuronal-firing-rate correlations (r = 0.70).Conclusions: Our results offer a resolution to a central controversy regarding the coupling between neurons, LFP, and BOLD signals by demonstrating, for the first time, that the coupling of single units to the other measures is variable yet it is tightly related to the degree of interneuronal correlations in the human auditory cortex.