The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex
The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex
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DOI：
10.1007/s00702-012-0845-4
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发表时间：
2012-12-01
影响因子：
3.3
通讯作者：
Uncini, A.
中科院分区：
文献类型：
--
作者：
Di Lazzaro, V.;Manganelli, F.;Uncini, A.
弱阴极经颅直流电刺激（tDCS）的人手区调节皮质脊髓兴奋性与经颅磁刺激（TMS）诱发的运动诱发电位（MEP）的抑制。如果给予tDCS几分钟，兴奋性的变化会持续超过刺激时间，并且可以保持稳定一小时或更长时间。本研究的目的是评估是否可以通过延长阴极tDCS（刺激20分钟）诱导皮质兴奋性的持久抑制。我们还探讨了脑源性神经营养因子（BDNF）基因多态性对tDCS后效的影响。在阴极tDCS 20分钟之前和之后长达24小时，评价了受刺激半球和对侧半球对单脉冲和成对脉冲TMS的皮质兴奋性。我们评估了MEP的阈值和幅度，短间隔皮质内抑制（SICI）和皮质内易化（ICF）。tDCS对MEP振幅产生明显的抑制作用，在刺激结束后3 h仍具有显著性。BDNF基因型对tDCS后效应无影响。对欧洲议会议员、国际刑事法院和国际刑事法院的保留不受影响。在对侧半球中未观察到显著影响。20分钟的阴极tDCS能够诱导对人类运动皮层兴奋性的长期抑制。
Weak cathodal transcranial direct current stimulation (tDCS) of the human hand area modulates corticospinal excitability with a suppression of motor-evoked potentials (MEPs) evoked by transcranial magnetic stimulation (TMS). The changes in excitability persist beyond the time of stimulation if tDCS is given for several minutes and can remain stable for an hour or more. The aim of present study was to evaluate whether a long-lasting suppression of cortical excitability could be induced by prolonged cathodal tDCS (20 min of stimulation). We also explored the impact of brain-derived neurotrophic factor (BDNF) gene polymorphisms, on tDCS after-effects. Cortical excitability to single and paired-pulse TMS was evaluated both for the stimulated and contralateral hemisphere, before and up to 24 h after 20 min of cathodal tDCS. We evaluated threshold and amplitude of MEPs, short interval intracortical inhibition (SICI), and intracortical facilitation (ICF). tDCS produced a pronounced suppression of MEP amplitude that was still significant at 3 h after the end of stimulation. The BDNF genotype had not influence on tDCS after-effects. Thresholds for MEPs, SICI and ICF were not affected. No significant effect was observed in the contralateral hemisphere. Twenty minutes of cathodal tDCS is capable of inducing a long-lasting suppression of the excitability of the human motor cortex.