The usefulness of high pre-operative levels of serum type I collagen bone markers for the prediction of changes in bone mineral density after parathyroidectomy
The usefulness of high pre-operative levels of serum type I collagen bone markers for the prediction of changes in bone mineral density after parathyroidectomy
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DOI：
10.3275/7923
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发表时间：
2012-07-01
影响因子：
5.4
通讯作者：
Moreno, E.
中科院分区：
文献类型：
--
作者：
Alonso, S.;Ferrero, E.;Moreno, E.
背景：I型胶原氨基末端前胶原前肽（P1NP）和I型胶原交联c末端末端肽（β CTX）是反映和监测原发性甲状旁腺功能亢进（PHPT）患者骨转换增加的两种更敏感的骨标志物。目的：本研究旨在评估西班牙PHPT患者甲状旁腺切除术（PTX）一年后I型胶原标志物的变化趋势，并探讨PTX术后血清P1NP和β CTX水平与骨密度（BMD）变化的关系。材料与方法：入选53例PHPT患者，随访1年，测量腰椎BMD、腰椎t评分、腰椎z评分、PTH、钙、磷、P1NP、β - CTX。结果：术前两种标志物浓度均升高（P1NP: 90.71 +/- 5.03; β CTX: 1.52 +/- 0.44）。术后平均β - CTX和P1NP浓度显著降低(p
Background: Amino-terminal procollagen propeptide of type I collagen (P1NP) and cross-linked C-terminal telopeptide of type I collagen (beta CTX) are two of the more sensitive bone markers for reflecting and monitoring patients with an increased bone turnover as observed in primary hyperparathyroidism (PHPT) patients. Aim: The present study was performed to evaluate the trend of type I collagen markers one year after parathyroidectomy (PTX) and to examine the relationships between serum P1NP and beta CTX levels and bone mineral density (BMD) change after PTX in PHPT Spanish patients. Materials and methods: Fifty-three PHPT patients were enroled and were followed for one year by measuring lumbar BMD, lumbar t-score, lumbar z-score, PTH, calcium, phosphorus, P1NP and beta CTX. Results: Pre-surgery concentrations of both markers were elevated (P1NP: 90.71 +/- 5.03; beta CTX: 1.52 +/- 0.44). A significant decrease was observed in mean post-operative beta CTX and P1NP concentrations (p